| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M.; McIntosh, J. Michael; Gray, William Robert |
| Other Author |
Cruz, Lourdes J. |
| Title |
γ-Carboxyglutamate in a neuroactive toxin |
| Date |
1984 |
| Description |
The venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of γ-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence of the sleeper peptide is Gly-Glu-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH3. |
| Type |
Text |
| Publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
| Journal Title |
Journal of Biological Chemistry |
| Volume |
259 |
| First Page |
14343 |
| Last Page |
14346 |
| Subject |
Conus geographus; Venom; Conotoxins; gamma-Carboxyglutamate; Neurotoxins |
| Subject LCSH |
Neurotoxic agents; Neuropeptides; Conus |
| Language |
eng |
| Bibliographic Citation |
McIntosh, J. M., Olivera, B. M., Cruz, L. J., & Gray, W. R. (1984). γ-Carboxyglutamate in a neuroactive toxin. Journal of Biological Chemistry, 259, 14343-6. |
| Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
| Format Medium |
application/pdf |
| Format Extent |
522,088 bytes |
| Identifier |
ir-main,8206 |
| ARK |
ark:/87278/s6x35g0m |
| Setname |
ir_uspace |
| ID |
706298 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6x35g0m |
