| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M.; McIntosh, J. Michael |
| Other Author |
Ellison, Michael |
| Title |
α-Conotoxins ImI and ImII: similar α7 nicotinic receptor antagonists act at different sites |
| Date |
2003 |
| Description |
A novel conotoxin, α-conotoxin ImII (α-CTx ImII), identified from Conus imperialis venom ducts, was chemically synthesized. A previously characterized C. imperialis conotoxin, α-conotoxin ImI (α-CTx ImI), is closely related; 9 of 12 amino acids are identical. Both α-CTx ImII and α-CTx ImI functionally inhibit heterologously expressed rat α7 nAChRs with similar IC50 values. |
| Type |
Text |
| Publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
| Journal Title |
Journal of Biological Chemistry |
| Volume |
278 |
| First Page |
757 |
| Last Page |
764 |
| Subject |
Conotoxins; Conotoxin ImI; Conotoxin ImII |
| Subject LCSH |
Conus; Marine toxins; Nicotinic receptors -- Antagonists |
| Language |
eng |
| Bibliographic Citation |
Ellison, M., McIntosh, J. M., & Olivera, B. M. (2003). α-Conotoxins ImI and ImII: similar α7 nicotinic receptor antagonists act at different sites. Journal of Biological Chemistry, 278, 757-64. |
| Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
| Format Medium |
application/pdf |
| Format Extent |
239,894 bytes |
| Identifier |
ir-main,8423 |
| ARK |
ark:/87278/s65q5dks |
| Setname |
ir_uspace |
| ID |
705880 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s65q5dks |
