| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Jorgensen, Erik |
| Other Author |
Williams, Stacey L.; Lutz, Suanne; Charlie, Nicole K.; Vettel, Christiane; Ailion, Michael; Coco, Cassabdra; Tesmer, John J. G.; Wieland, Thomas; Miller, Kenneth G. |
| Title |
Trio's Rho-specific GEF domain is the missing Gaq effector in C. elegans |
| Date |
2007-11-01 |
| Description |
The Gaq pathway is essential for animal life and is a central pathway for driving locomotion, egg laying, and growth in Caenorhcibditis elegans, where it exerts its effects through EGL-8 (phospholipase CB [PLCB]) and at least one other effector. To find the missing effector, we performed forward genetic screens to suppress the slow growth and hyperactive behaviors of mutants with an overactive Gaq pathway. |
| Type |
Text |
| Publisher |
Cold Spring Harbor Lab Press |
| Journal Title |
Genes & Development |
| Volume |
21 |
| Issue |
21 |
| First Page |
2731 |
| Last Page |
2746 |
| DOI |
10.1101/gad.1592007 |
| citatation_issn |
0890-9369 |
| Language |
eng |
| Bibliographic Citation |
Williams, S. L.; Lutz, S.; Charlie, N. K.; Vettel, C.; Ailion, M.; Coco, C.; Tesmer, J. J. G.; Jorgensen, E.; Wieland, T.; Miller, K. G. (2007). Trio's Rho-specific GEF domain is the missing Gaq effector in C. elegans. Genes and Development, 21 (21), 2731-46. |
| Rights Management |
(c) Cold Spring Harbor Laboratory Press-CSHL Press |
| Format Medium |
application/pdf |
| Format Extent |
6,963,331 bytes |
| Identifier |
ir-main,6265 |
| ARK |
ark:/87278/s6hh73jd |
| Setname |
ir_uspace |
| ID |
705596 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6hh73jd |
