Elevated Serum Hepcidin and Increased Hepcidin Synthesis in Biopsy Specimens in Patients with Giant Cell Arteritis

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Identifier 20090224_nanos_posters_095.pdf
Title Elevated Serum Hepcidin and Increased Hepcidin Synthesis in Biopsy Specimens in Patients with Giant Cell Arteritis
Creator Katz, Bradley; De Domenico, Ivana; Koening, Curry; Digre, Kathleen; Warner, Judith; Kaplan, Jerry
Subject Giant cell arteritis; Temporal Arteritis; Hepcidin; RT-PCR; lipopolysaccharide
Description Hepcidin is a 25amino acid disulfide-rich peptide that acts as a systemic iron-regulatory hormone. Hepcidin synthesis increases during inflammation, trapping iron in macrophages and decreasing plasma iron concentrations. Increased hepcidin synthesis underlies the phenomenon of the anemia of chronic disease. Hepcidin was recently thought to be produced exclusively in the liver, but has recently been shown to be synthesized in Mller cells, where hepcidin appears to regulate retinal iron levels.
Date 2009-02-24
Language eng
Format application/pdf
Format Creation application/pdf
Type Text
Source 2009 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS 2009: Poster Presentations
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Rights Management Copyright 2010. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s612900x
Context URL The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/
Contributor Secondary Steven Galetta, MD; Lynn Gordon, MD, PhD
Setname ehsl_novel_nam
ID 180501
Reference URL https://collections.lib.utah.edu/ark:/87278/s612900x